Covid-19 Vaccination – Why Should You Get Vacinated? Full Details!
Covid-19, called Coronavirus is shaking the entire world causing total change of life style of the people. The impact was seen in almost all the sectars – Social, Economical, Political development.
Many persons have doubts whether one should need Covid-19 vaccination.
The honest advice is – Yes, you should go for Covid-19 vaccination.
What the vaccines do to protect us from Covid-19 Viruses and its variants?
The answer is simple. A Covid-19 Vaccine just makes our body’s immune system well prepared with a defense mechanism to face coronavirus if the person gets infected.
How Covid-19 vaccination prepares the body?
Simply by introducing the deactivated coronavirus ingredients to the body through the vaccine. So, our body gets the new alert after vaccination and becomes prepared to face such virises in future by creating a defense mechanism.
Such vaccination practices are already done right from our birth for many infections such as Cholera, Polio, Hepatitis B, etc.
Covid Vaccine is also a preventive step like that.
So, it is a wise decision to get vaccinated.
Won’t we get infection in future if we get Covid-19 vaccination?
Not so. Infections may occur because of our exposure to the virus. However, the vaccines may help to avoid serious complications because of the infection and it may also prevent death-level advancement of the infection.
So, Get vaccinated. It is safer than facing Covid-19 directly.
Before that, learn the technologies behind all the vaccines in this world. Thanks to World Health organization (WHO) for these details published by them!
TECHNOLOGIES BEHIND COVID VACCINES
(1) As of December 2020, there are over 200 vaccine candidates for COVID-19 being developed. Of these, at least 52 candidate vaccines are in human trials.
(2) WHY ARE THERE SO MANY VACCINES IN DEVELOPMENT?
Typically, many vaccine candidates will be evaluated before any are found to be both safe and effective. For example, of all the vaccines that are studied in the lab and laboratory animals, roughly 7 out of every 100 will be considered good enough to move into clinical trials in humans. Of the vaccines that do make it to clinical trials, just one in five is successful. Having lots of different vaccines in development increases the chances that there will be one or more successful vaccines that will be shown to be safe and efficacious for the intended prioritized populations.
(3) DIFFERENT TYPES OF VACCINES
There are three main approaches to designing a vaccine. Their differences lie in whether they use a whole virus or bacterium; just the parts of the germ that triggers the immune system; or just the genetic material that provides the instructions for making specific proteins and not the whole virus.
(4) The whole-microbe approach:
(i) Inactivated vaccine
The first way to make a vaccine is to take the disease-carrying virus or bacterium, or one very similar to it, and inactivate or kill it using chemicals, heat or radiation. This approach uses technology that’s been proven to work in people – this is the way the flu and polio vaccines are made – and vaccines can be manufactured on a reasonable scale.
However, it requires special laboratory facilities to grow the virus or bacterium safely, can have a relatively long production time, and will likely require two or three doses to be administered.
(ii) Live-attenuated vaccine
A live-attenuated vaccine uses a living but weakened version of the virus or one that’s very similar. The measles, mumps and rubella (MMR) vaccine and the chickenpox and shingles vaccine are examples of this type of vaccine. This approach uses similar technology to the inactivated vaccine and can be manufactured at scale. However, vaccines like this may not be suitable for people with compromised immune systems.
(iii) Viral vector vaccine
This type of vaccine uses a safe virus to deliver specific sub-parts – called proteins – of the germ of interest so that it can trigger an immune response without causing disease. To do this, the instructions for making particular parts of the pathogen of interest are inserted into a safe virus. The safe virus then serves as a platform or vector to deliver the protein into the body. The protein triggers the immune response. The Ebola vaccine is a viral vector vaccine and this type can be developed rapidly.
(5) SUB UNIT APPROACH:
A subunit vaccine is one that only uses the very specific parts (the subunits) of a virus or bacterium that the immune system needs to recognize. It doesn’t contain the whole microbe or use a safe virus as a vector. The subunits may be proteins or sugars. Most of the vaccines on the childhood schedule are subunit vaccines, protecting people from diseases such as whooping cough, tetanus, diphtheria and meningococcal meningitis.
(6) THE GENETIC APPROACH (NUCLEIC ACID VACCINE)
Unlike vaccine approaches that use either a weakened or dead whole microbe or parts of one, a nucleic acid vaccine just uses a section of genetic material that provides the instructions for specific proteins, not the whole microbe. DNA and RNA are the instructions our cells use to make proteins. In our cells, DNA is first turned into messenger RNA, which is then used as the blueprint to make specific proteins.
(7) A nucleic acid vaccine delivers a specific set of instructions to our cells, either as DNA or mRNA, for them to make the specific protein that we want our immune system to recognize and respond to.
The nucleic acid approach is a new way of developing vaccines. Before the COVID-19 pandemic, none had yet been through the full approvals process for use in humans, though some DNA vaccines, including for particular cancers, were undergoing human trials. Because of the pandemic, research in this area has progressed very fast and some mRNA vaccines for COVID-19 are getting emergency use authorization, which means they can now be given to people beyond using them only in clinical trials.
WHAT TYPES OF VACINES INDIA’s COVISHIELD & COVACXIN ARE?
(i) Covaxin is an India’s Indigenous inactivated viral vaccine manufactured by Bharath Biotech. This vaccine is developed with Whole-Virion Inactivated Vero Cell-derived technology. Though they contain inactivated viruses, they can not infect a person but still can teach the immune system to prepare a defence mechanism against the active virus.
(ii) Covishield is being prepared being developed by the Oxford-AstraZeneca and is being manufactured by the Serum Institute of India (SII) using the viral vector platform. In this technology, A chimpanzee adenovirus – ChAdOx1 – has been modified to enable it to carry the COVID-19 spike protein into the cells of humans. This cold virus is basically incapable of infecting the receiver but can very well teach the immune system to prepare a mechanism against such viruses.
Covid-19 vaccination is just free in India and many countries of the world. Use this gesture of the governments. Do get vaccinated and be safe.
(CORONAVIRUS DISEASE (COVID-19)- PRECAUTIONS & MANAGEMENT! READ HERE!)